| 저자 |
Ki Sung Kim, Moon Hyoung Lee, Kwon Soo Jung, Tae Hoon Kim, Seok-hyung Kim, Hoon Young Choi, Hyeong Cheon Park, Hyunwook Kim |
| 초록 |
Objectives: Serum levels of sodium and potassium have been recognized to be closely associated with the incidences of various cardiovascular events. However, the association of serum levels of sodium and potassium and coronary artery calcification, as a validated marker of subclinical atherosclerosis, has not been addressed to date, therefore, in this study, we aimed to determine their relationships.
Methods: A total of 5,977 individuals without prior cardiovascular diseases were included. All of the participants underwent multidetector computed tomography for the evaluation of coronary artery calcification (CAC) during their health check-ups. The subjects were divided into three groups according to CAC scores (group 1: 0; group 2: 1–399; group 3: ≥400).
Results: After controlling for other confounders, the results of ordinal logistic regression analyses showed that a lower sodium level [odds ratio (OR) with 95% CI of 1 mmol/L decrease for being in a more advanced CAC group; 1.05 (1.02-1.08), P<0.001], a higher potassium-to-sodium ratio [OR with 95% CI of 1 percent increase for being in a more advanced CAC group; 1.68 (1.27-2.23), P<0.001], and a higher potassium level [OR with 95% CI of 1 mmol/L increase for being in a more advanced CAC group; 1.36 (1.11-1.67), P=0.003] were all independently associated advanced stage of CAC
Conclusions: Serum levels of sodium and potassium and their ratio were all associated with the degree of CAC. These results might explain the background of the close relationships between serum levels of sodium and potassium, and various cardiac outcomes.
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