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논문분류 춘계학술대회 초록집
제목 Serum levels of sodium and potassium are independently associated with the degree of coronary artery calcification: A single-center cross-sectional study
저자 Ki Sung Kim, Moon Hyoung Lee, Kwon Soo Jung, Tae Hoon Kim, Seok-hyung Kim, Hoon Young Choi, Hyeong Cheon Park, Hyunwook Kim
출판정보 2018; 2018(1):
키워드 coronary artery calcification | serum sodium | serum potassium | potassium-to-sodium ratio
초록 Objectives: Serum levels of sodium and potassium have been recognized to be closely associated with the incidences of various cardiovascular events. However, the association of serum levels of sodium and potassium and coronary artery calcification, as a validated marker of subclinical atherosclerosis, has not been addressed to date, therefore, in this study, we aimed to determine their relationships. Methods: A total of 5,977 individuals without prior cardiovascular diseases were included. All of the participants underwent multidetector computed tomography for the evaluation of coronary artery calcification (CAC) during their health check-ups. The subjects were divided into three groups according to CAC scores (group 1: 0; group 2: 1–399; group 3: ≥400). Results: After controlling for other confounders, the results of ordinal logistic regression analyses showed that a lower sodium level [odds ratio (OR) with 95% CI of 1 mmol/L decrease for being in a more advanced CAC group; 1.05 (1.02-1.08), P<0.001], a higher potassium-to-sodium ratio [OR with 95% CI of 1 percent increase for being in a more advanced CAC group; 1.68 (1.27-2.23), P<0.001], and a higher potassium level [OR with 95% CI of 1 mmol/L increase for being in a more advanced CAC group; 1.36 (1.11-1.67), P=0.003] were all independently associated advanced stage of CAC Conclusions: Serum levels of sodium and potassium and their ratio were all associated with the degree of CAC. These results might explain the background of the close relationships between serum levels of sodium and potassium, and various cardiac outcomes.
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