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논문분류	춘계학술대회 초록집
제목	The association between neutrophil activation marker and arteriovenous fistula stenosis
저자	Hye Min Choi, Young Eun Kwon, Dong Jin Oh
출판정보	2018; 2018(1):
키워드	arteriovenous fistula \| stenosis \| inflammation \| neutrophil \| lactoferrin
초록	Objectives: Although arteriovenous fistula (AVF) dysfunction is a major cause of morbidity in hemodialysis (HD) patients, detailed pathogenesis of AVF stenosis is still under investigation. Inflammation and leukocytes have been shown to play an important role in the development AVF stenosis. Nevertheless, prior reports have focused on cells of monocyte lineage, and little is known about the possible role of neutrophils. We aimed to evaluate the association between AVF stenosis and neutrophil activation by examining lactoferrin, neutrophil elastase (NES), and angiogenin, which are markers of neutrophil activation and inhibition, respectively Methods: We examined serum levels of lactoferrin, NES, and angiogenin as well as other clinical and biochemical parameters in 54 patients who received HD with native AVF for more than 3 months. Degree of AVF stenosis was expressed by the percent of the greatest stenotic diameter to the widest adjacent vessel diameter by ultrasound Results: Lactoferrin and NES level were strongly correlated with each other (r=0.809, p=0.000). The degree of AVF stenosis was positively correlated with Lactoferrin (r=0.282, p=0.039) and NES (r=0.278, p=0.042) levels. However there was no significant correlation between AVF stenosis and Angiogenin level. Patients with severe AVF stenosis (stenosis > 50%) were older (67.9±8.3 vs 57.2±14.3, p=0.007), had longer dialysis vintage (7.0±4.0 vs 4.3±4.0 yr, p=0.027), longer duration of AVF use (6.9±4.0 vs 3.8±3.5 yr, p=0.008), and higher lactoferrin (11.9±6.5 vs 6.2±3.0 ng/ml, p=0.004) and NES levels (414.9±294.5 vs 228.0±154.5 ng/ml, p=0.027) compared with the other group. In multivariable analysis, however, there was no statistically significant factors that affect AVF stenosis Conclusions: Serum levels of Lactoferrin and NES, markers of neurophil activation, were marginally associated with AVF stenosis. Larger scale studies are needed to show whether they could be used as independent predictors of at-risk AVF
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