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논문분류	춘계학술대회 초록집
제목	Association between the ACTYP2 polymorphisms and risk of IgAN in a Chinese Han population
저자	Jiali Wei, Chunyang Ma, Yin Zhang, Wenning Li, Daofa Zhang
출판정보	2018; 2018(1):
키워드	IgA nephropathy \| ACYP2 \| polymorphisms \| Case-control \| Chinese Han
초록	Objectives: ACYP2 polymorphisms were reported to be associated with various diseases. However, the association between ACYP2 polymorphisms and IgA nephropathy (IgAN) risk in a Chinese Han population remains unclear. We aimed to evaluate the association between ACYP2 polymorphisms and IgAN risk by performed a case-control study. Methods: A total of 911 subjects were enrolled, including 416 IgAN patients and 495 healthy controls. Twelve single nucleotide polymorphisms (SNPs) in ACYP2 were genotyped using the Sequenom MassARRAY platform. Odds ratio (OR) and 95% confidence interval (CI) were calculated to evaluate the association of ACYP2 polymorphisms with IgAN risk. Results: We observed that the rs843720 allele G was significantly more frequent in cases than controls, and was associated with an increased IgAN risk (allele G: OR = 1.23, 95 % CI: 1.01-1.49, P = 0.036; dominant: adjusted OR = 1.55, 95 % CI: 1.01-2.37, P = 0.044; log-additive: adjusted OR = 1.43, 95 % CI: 1.04-1.95, P = 0.026). In addition, we found that rs12615793 had significantly increased the risk of IgAN in the recessive model (adjusted OR = 3.33, 95 % CI: 1.05-10.51, P = 0.042). Conclusions: The present study indicated that rs843720 and rs12615793 were associated with increased IgAN risk in Chinese Han population, and ACYP2 polymorphisms may inﬂuence the progression of IgAN. However, more functional and association studies with larger sample sizes should be performed to further validate our results in the future. Figure 1: Haplotype block map for the eleven SNPs in ACYP2
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