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논문분류	춘계학술대회 초록집
제목	Role of retinoic acid signaling in chronic kidney disease
저자	Jin Joo Cha1, Young Sun Kang1, Ho Jun Lee1, Jungyeon Ghee1, Ji Ae Yoo1, Hye Sook Min2, Ji Eun Lee2, Jee Young Han3, Dae Ryong Cha1
출판정보	2018; 2018(1):
키워드	retinoic acid signaling \| fibrosis \| RARs
초록	Objectives: Retinoic acid(RA) signaling is activated during developmental stage during generation and differentiation of the kidney, therefore it may be involved in regeneration process of kidney injury. In this study, we investigated the changes in the expressions of retinoic acid signaling during the process of chronic kidney injury using mice model of unilateral ureteral obstruction (UUO) model. Methods: Chronic kidney injury was induced by UUO surgery in 6 week-old B6 mice. The expressions of kidney RA signaling ere examined at baseline and day5, day 14 after surgey. The correlation of RA signaling and kidney tubular injury was examined Results: As expected, tubulointerstitial inflammation and fibrosis were significantly accelerated after day 5 UUO. Renal cortex gene expressions of retinoic nuclear receptors, RARα and RARβ were downregulated during initial time course (day5), whereas at day14 their gene and protein expressions were significantly upregulated. Among enzymes that are responsible for retinoic acid synthesis, Aldh1α1 showed similar pattern with RARα and RARβ. Rate limiting enzyme Aldh1α2 was the most upregulated gene during the time course, starting from the early phase of injury. PDGFR beta a marker for fibroblast/myofibroblast in the kidney correlated with the expression of Aldh1a2. Conclusions: During initial phase of unilateral ureteral obstruction, key ligands for RA signaling are downregulated which at later stages, all RA signaling pathways were upregulated. Further study on the effect of ATRA as a preventive agent is ongoing, alongside to myofibroblast precursor renal pericytes.
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