대한신장학회

논문분류	춘계학술대회 초록집
제목	Comparison of the impact of Kidney Donor Profile Index on the Post-Transplant Clinical Outcomes between Elderly and Young Kidney Transplant Recipients; Multicenter Cohort Study
저자	Woo Yeong Park1, Jong Hoon Lee2, Young Soo Kim3, Bum Soon Choi2, Cheol Whee Park2, Chul Woo Yang2, Yong-Soo Kim2, Kyubok Jin1, Seungyeup Han1, Byung Ha Chung2
출판정보	2018; 2018(1):
키워드	Kidney transplantation \| Age \| Delayed graft function \| Graft rejection \| Graft survival
초록	Objectives: We investigated the clinical significance of Kidney Donor Profile Index (KDPI) system for the prediction of the clinical outcomes of elderly- or young kidney transplant recipients (KTRs) in deceased donor kidney transplantation (DDKT). Methods: Four hundred sixty-nine KTRs receiving kidneys from 356 deceased donors (DDs) were included from three transplant centers in this study. We divided high KDPI and low KDPI by 67%, which is the median value of KDPI score, and divided into elderly KTRs and young KTRs at 60 years of age. We investigated the incidence of delayed graft function (DGF), biopsy-proven acute rejection (BPAR), allograft survival and patient survival rates between elderly KTRs and young KTRs donated from DDs with high KDPI- or low KDPI score. Results: The study analyzed 62 (13.2%) elderly KT cases and 407 (86.8%) young KT cases. In the elderly KT and young KT groups, 39 (62.9%) and 191 (46.9%) KTs involved a donor with high KDPI score, respectively. There were no significant differences in the incidence of DGF and BPAR between elderly KT and young KT groups donated from DDs with high KDPI- or low KDPI score. In the elderly KT group, there was no significant difference of death-censored graft survival and patient survival rates between high KDPI-KT and low KDPI-KT. However, in the young KT group, high KDPI-KT group was significantly lower in death-censored graft survival and patient survival rates compared with low KDPI-KT group (P=0.001, P=0.015). Among high KDPI-elderly KT group, high KDPI-young KT group, low KDPI-elderly KT group, and low KDPI-young KT group, high KDPI-young KT group had the lowest death-censored graft survival rate (P=0.001), but there was no significant difference in patient survival rate among them. Conclusions: High KDPI in DDs showed significant adverse impact on the allograft survival in young KTRs, but it was not prognostic factor in elderly KTRs.
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