대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Omega 3 fatty acid ameliorate the puromycin induced podocyte injury.
저자	Jiwon Lee1, Hyunsu Choi4, Jin Young Jeong3, Yoon-Kyung Chang2, Dae Eun Choi3, Ki Ryang Na3, Kang Wook Lee3, Jwa-Jin Kim3
출판정보	2018; 2018(1):
키워드	omega 3 \| podocyte \| puromycin
초록	Objectives: Podocyte injury are activation of autophagy, including mitophagy, is considered to be an important factor in podocyte injury. Recent our study revealed that omega 3 increased autophagic flux in acute kidney injury models. In this work, we identified the role of omega-3 in autophagy in the puromycin-induced podocyte injury model. Methods: we used the immortalized mice podocytes. Puromycin was treated in podocyte by dose and time. Omega 3 (EPA, DHA) were treated in podocyte with vehicle or puromycin by dose and time. Autophagic markers are evaluated. Oxidative stress and autophagic markers and cytoskeleton stains were evaluated. Results: Puromycin treatment increased the stress fiber(f-actin). Omega 3 treatment improved the f-actin fragmentation in puromycin treated podocytes. Omega 3 treatment Box/Bcl2 ration in puromycin treated podocytes. Puromcyin treatement increased the LC3 in immortalized podocytes.However, omega 3 treatment increased the LC3 in puromycin treated podocytes, compared to vehicle treated podocytes. p62 was decreased in both omega 3 and vehicle treated puromycin injured podocytes. Conclusions: Omega 3 amerliorates the puromycin induced podocyte injury.
원문(PDF)	PDF 원문보기

목록

위로가기