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논문분류	춘계학술대회 초록집
제목	Microscopic hematuria is a risk factor of incident chronic kidney disease in the general population: a community-based prospective cohort study
저자	Hyoungnae Kim, Ki Heon Nam, Seohyun Park, Jong Hyun Jhee, Hae-Ryong Yun, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
출판정보	2018; 2018(1):
키워드	microscopic hematuria \| chronic kidney disease \| proteinuria \| urologic cancer
초록	Objectives: Although asymptomatic microscopic hematuria (MH) is a common finding in clinical practice, its long-term outcome remains unknown. This study evaluated the clinical implication of MH in the general population using a large-scale long-term longitudinal cohort database. Methods: This prospective observational cohort study included 8719 participants from the Korean Genome and Epidemiology Study between 2001 and 2014. MH was defined as ≥5 red blood cells per high-power field in random urinalysis without evidence of pyuria. The primary study outcome measure was incident chronic kidney disease (CKD), defined as estimated glomerular filtration rate (eGFR) <60 mL min-1×1.73×m-2. Results: During a median follow-up of 11.7 years, CKD occurred in 677 (7.8%) subjects. In Cox regression after adjustment for multiple confounders, subjects with MH had a significantly higher risk of incident CKD than those without [hazard ratio (HR), 1.45; 95% CI, 1.12–1.87; P=0.005]. Isolated MH without proteinuria was also a risk factor of incident CKD (HR, 1.37; 95% CI, 1.04–1.79; P=0.023) and the risk was further increased in MH with concomitant proteinuria (HR, 5.41; 95% CI, 2.54–11.49; P<0.001). In propensity score matching analysis after excluding subjects with proteinuria, multivariable stratified Cox regression analysis revealed that subjects with isolated MH had a significantly higher risk of incident CKD than those without (HR, 1.83; 95% CI, 1.14–2.94; P=0.012). Conclusions: The presence of MH is associated with an increased risk of incident CKD in the general population. Therefore, attentive follow-up is warranted in persons with MH for early detection of CKD. Figure 1. Cumulative incidence of CKD according to the presence of isolated MH and proteinuria. Abbreviations: CKD, chronic kidney disease; MH, microscopic hematuria.
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