대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	The effect of serum uric acid on renal function
저자	Se Won Oh, Hyunseo Kim, Ki joon Lim, Jihyun Yang, Myung-gyu Kim, Sang-Kyung Jo, Won-Yong Cho
출판정보	2018; 2018(1):
키워드	Chronic kidney disease \| Diabetes \| glomerular filtration rate \| Hypertension \| Uric acid
초록	Objectives: Hyperuricemia is related to increased risk of cardiovascular mortality and mortality. Uric acid is associated with activation of renin-angiotensin system, oxidative stress, and inflammation. However, the effect of uric acid on renal function was controversial. Methods: Among the 56,367 adult participants who underwent health check-ups during 2004-2017, we included 16,695 participants with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73m2 and repeated measurements of uric acid and eGFR. We divided participants into sex-specific quartile groups according to the baseline serum uric acid level. The decline of renal function aggravation was defined by the decrease in eGFR by more than 25%. Results: The average age of the participants was 46.7±12.5 years, baseline eGFR was 91.1 ± 13.7 ml/min/1.73m2, and 52.5% were male. During 54.3± 37.5 months of follow up period, the decline of renal function was the highest in the highest quartile of serum uric acid (0.9%, 1.0%, 1.4% and 1.7%; lowest, second, third, and highest quartiles, respectively; P=0.002). The development of chronic kidney disease (CKD) (eGFR <60 ml/min/1.73m2) was the highest in the highest uric acid group (0.7%, 0.6%, 1.2% and 2.5%; lowest, second, third, and highest quartiles, respectively; P<0.001). The multivariate cox regression analysis showed that risks of hypertension and diabetes development were significantly increased in the third and highest quartiles (P<0.001). The risks of decline in renal function were significantly higher in the third (RR, 2.280; 95% CI 1.468-3.542) and highest quartile (RR, 2.982; 95% CI 1.910-4.656) compared than the lowest quartile. The participants with highest quartile showed 2.322-fold risk elevation of CKD development (95% CI 1.486-3.630). Conclusions: The decline of renal function significantly increased in participants with higher baseline uric acid levels. Serum uric acid levels were associated with the development of hypertension, diabetes, and CKD.
원문(PDF)	PDF 원문보기

목록

위로가기