대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Predictive factors for progression of chronic kidney disease in children: Results from a national cohort study
저자	Yo Han Ahn1, Hyun Jin Choi2, Seong Heon Kim3, Kyung Hee Han4, Min Hyun Cho5, Hee Yeon Cho6, Joo Hoon Lee7, Hee Gyung Kang2, Young Seo Park7, Il-Soo Ha2
출판정보	2018; 2018(1):
키워드	chronic kidney disease \| children \| disease progression
초록	Objectives: The prevalence of chronic kidney disease (CKD) in children has increased over the last decades. Comprehensive studies on pediatric CKD are rare in Asian countries. We aimed to evaluate predictive factors for the progression of CKD using a national pediatric cohort study, KNOW-Ped CKD (KoreaN cohort study for Outcome in patients With Pediatric CKD). Methods: From 437 enrolled pediatric patients with stage 1 to 5 of CKD, 432 patients who followed up at least 6 months between July 2011 and May 2017, were reviewed. The progression of CKD was defined as a composite renal event of renal replacement therapy (RRT) or a 50% decline in glomerular filtration rate. The baseline clinical and laboratory variables included in the analysis. Results: The progression of CKD was occurred in 136 (31.4%) patients after median follow ups of 1.9 (IQR 0.7-3.2) years. In Kaplan-Meier analysis, the median renal survival of all included CKD patients was estimated as 5.2 years. The progression of CKD was shorter in patients with glomerulopathy than non-glomerulopathy patient (5.1 years vs. 5.3 years, log-rank test P =0.008). In multivariate analysis, after adjustment with Cox regression model, 6 variables remained as independent predictive factors of CKD progression: boy, CKD stage 4 and 5, left ventricular hypertrophy, urine protein/creatinine ratio ≥2.0 mg/mg, serum albumin <3.8 mg/dL, and anemia. Among them, hypoalbuminemia and anemia could be modifiable and treatable. Conclusions: Using a national cohort, we could confirm the risk factors for CKD progression. Modifiable factors could be implied in clinical management of pediatric CKD patients.
원문(PDF)	PDF 원문보기

목록

위로가기