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논문분류	춘계학술대회 초록집
제목	Association between blood urea nitrogen to creatinine ratio and the risk of chronic kidney disease.
저자	Hyang Ki Min, So Young Lee, Sung Woo Lee
출판정보	2018; 2018(1):
키워드	blood urea nitrogen to creatini \| chronic kidney disease \| hydration
초록	Objectives: Clinical significance of dehydration on chronic kidney disease (CKD) has not been fully evaluated, particularly in large community-dwelling population. Methods: We used data from 28,342 adult participants of Korean National Health and Nutritional Examination Survey. Systemic dehydration was evaluated using blood urea nitrogen to creatinine ratio (BUN/Cr) and kidney function was calculated using creatinine-based estimated glomerular filtration rate (eGFR). The association between BUN/Cr and eGFR was analyzed using multivariate linear regression analysis, and the potential non-linearity and threshold evaluation was performed using a generalized additive model (GAM). The relationship between BUN/Cr and CKD was evaluated using multivariate logistic regression analysis, and the potential non-linear association was analyzed using penalized spline curve analysis. Results: Of the total 28342 participants, mean BUN/Cr was 18.0 and mean eGFR was 94.6 ml/min/1.73 m2. In multivariate linear regression analysis, eGFR significantly increased as BUN/Cr increased. Using GAM analysis, eGFR was steadily increased without definite threshold with the increase of BUN/Cr. The odds of CKD were increased with the decrease of BUN/Cr quartile; odds ratio (OR) and 95% confidence interval (CI) of 3Q, 2Q, and 1Q compared to 4Q of BUN/Cr were 2.264 (1.179-2.880, P <0.001), 2.910(2.270-3.729, P <0.001), and 5.552 (4.309-7.154, P <0.001), respectively. In visual inspection in penalized spline curve analysis, the OR for CKD was abruptly increased below 10 of BUN/Cr. Conclusions: As BUN/Cr increased, eGFR significantly increased. Similarly, the odds for CKD was significantly increased as BUN/Cr decreased, suggesting potential positive impact of dehydration on kidney function. Future studies need to confirm our cross-sectional results. Table 1,2 and 3
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