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논문분류	춘계학술대회 초록집
제목	The Framingham Score as a Useful Predictor of Incident Chronic Kidney Disease
저자	Changhyun Lee, JooWhan Kim, Sang Mi Lee, Ki Heon Nam, Hae-Ryong Yun, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, SeungHyeok Han
출판정보	2018; 2018(1):
키워드	CKD \| Framingham
초록	Objectives: The Framingham risk score is a well-validated method to estimate cardiovascular risk and has been used worldwide in clinical practice. Given many common risk factors between cardiovascular disease (CVD) and chronic kidney disease (CKD), it can be hypothesized that the Framingham risk score can also predict the future development of CKD. Here, we tested whether this score system can perform well and correctly predict incident CKD in general population. Methods: Using the database from the Korean Genome and Epidemiology Study, we analyzed 8,778 subjects who had normal renal function and had no prior history of CVD. Subjects were classified into low (<10%, n=5,356 [61.0%]), intermediate (10~20%, n=2,223 [25.3%]), and high (>20%, n=1199, [13.7%]) risk groups based on the Framingham risk score at baseline. The primary endpoint was de novo development of CKD, defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2. Results: The mean age was 51.7 years and 4111 (46.8%) were male. During a mean follow-up duration of 8.5 ± 4.3 years, 178 (3.3%), 255 (11.5%), and 242 (20.2%) subjects developed CKD in the low, intermediate, and high risk group, respectively (P<0.001). In multivariable analysis after adjustment of eGFR, BMI, alcohol, fasting glucose, CRP, education, and income, the high risk group was significantly associated with increased risk of incident CKD compared to the low risk group (hazard ratio [HR], 4.556; 95% confidence interval [CI], 3.308 to 6.274; P<0.001). In addition, the intermediate risk group also conferred a 2.5 fold increased risk of CKD development (HR, 2.521; 95% CI, 1.879 to 3.382; P<0.001). Subgroup analyses showed that this association was consistently observed irrespective of age, sex, obesity, or hypertension. Conclusions: The Framingham risk score well predicts the development of incident CKD in general population with normal renal function. Table2. Cox regression analysis according to Framingham risk score
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