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논문분류	춘계학술대회 초록집
제목	Prognostic impact of serum osteoprotegerin on renal disease progression in non-dialytic patients with chronic kidney disease
저자	Chana Myoung, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
출판정보	2018; 2018(1):
키워드	Non-dialysis \| CKD \| osteoprotegerin \| progress
초록	Objectives: In patients with chronic kidney disease (CKD), osteoprotegerin is considered to be an important regulator of bone metabolism and vascular calcification. However, the role of osteoprotegerin on the progression of renal dysfunction has not yet been well defined. The purpose of this study was to investigate the prognostic impact of osteoprotegerin in declining renal function in patients with CKD. Methods: We analyzed 2238 patients who were collected from 2011 to 2017 using The KoreaN Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD) dataset. A total of 1454 patients were enrolled after excluding 784 patients whose osteoprotegerin values were not measured. Primary outcomes included the incidence of end stage renal disease and ≥ 50% decline in estimated glomerular filtration rate (eGFR). Results: During an average follow-up of 3.40 years, 361 patients had eGFR reduction of more than 50% or progressed to end stage renal disease. A multivariable-adjusted logistic regression model confirmed that osteoprotegerin was significantly associated with renal outcome [Odds ratio (OR), 1.10; 95% confidential interval (CI), 1.03-1.18; p=0.003]. In the Cox regression analysis after adjustment of confounding factors, OPG level was independently associated with primary renal outcome [hazard ratio (HR), 1.09; 95% confidence interval (CI), 1.05-1.13; p<0.001]. Conclusions: Osteoprotegerin level is independently associated with declining of renal function in patients with CKD. These findings suggest that serum osteoprotegerin may be a predictor of progression to end stage renal disease in CKD patients. Table 1.Multivariable logistic regression analysis for the relationship between serum osteoprotegerin and total renal event in patient with CKD
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