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논문분류	춘계학술대회 초록집
제목	Data-driven Approaches for efficient drug discovery
저자	Wan Kyu Kim
출판정보	2018; 2018(1):
키워드	Systems Pharmacology \| Precision Medicine \| data driven drug discovery
초록	Objectives: Data-driven drug discovery (D4) exploits a comprehensive set of ‘Big’ data in order to provide an efficient path to new drug development. Methods: We present in silico chemical genomic approaches for target discovery & identification of drug repositioning (DR) candidates for cancer precision medicine. It is based on a recent large-scale dataset of ~20,000 drug-induced expression profiles in multiple cancer cell lines, which provides i) a global impact of transcriptional perturbation of both known targets and unknown off-targets, and ii) rich information on drug’s mode-of-action. Results: Here, we present several cases for target discovery & drug repositioning (DR) based on large-scale drug-induced expression profiles, or CMAP. Conclusions: .
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