대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Early change in estimated GFR and renal outcome in patient with chronic kidney disease; comparison of creatinine-based and cystatin-C-based eGFR slope
저자	Suhyun Kim, Hye Ryoun Jang, Woosung Huh, Yoon-Goo Kim, Dae Joong Kim, Ha Young Oh, Jung Eun Lee
출판정보	2018; 2018(1):
키워드	Chronic Kidney Disease \| progression \| estimated glomerular filtration \| creatinine \| cystatin C
초록	Objectives: This study compared the performance of creatinine-based eGFR slope (eGFRcre slope) with that of cystatin-C-based eGFR slope (eGFRcys slope) in identifying a high-risk group of progression to end-stage renal disease (ESRD) in patients with CKD. Methods: From October 2012 to May 2017, patients who had simultaneous measurements of serum creatinine and cystatin C more than 3 times for 1 year were identified. We calculated baseline eGFR values and one-year eGFR slopes using all measurements of serum creatinine and cystatin C. The patients with baseline eGFR ≥ 60 mL/min/1.73m2 were excluded. We defined a rapid progression as eGFR slope < -5 mL/min/1.73m2/year. Primary outcomes were progression to ESRD. Results: Total 1323 patients were included. Baseline eGFRcre were 39 (27 – 48) mL/min/1.73m2 and eGFRcys were 38 (27 – 50) mL/min/1.73m2. During follow-up of 2.9 (2.0 – 3.8) years, 134 (10%) subjects progressed to ESRD. Both eGFRcre slope and eGFRcys slope were associated with higher risk of ESRD, independently of baseline eGFR (HR = 0.986 [0.982 – 0.991], HR = 0.988 [0.983 – 0.993], respectively, all P < 0.001). Both creatinine and cystatin C based-rapid progression were associated with increased risk of ESRD (HR = 2.22 [1.57 – 3.13], HR = 2.03 [1.44 – 2.86], respectively, all P < 0.001). In subgroup analyses on rapid progression group by creatinine (N = 503), eGFRcys slope was not associated with risk of ESRD (HR = 0.96 [0.88 – 1.04], P = 0.31). Whereas, eGFRcre slope contributed to further discrimination of higher risk of ESRD in subjects with rapid progression by cystatin C (N=463) (HR = 0.91 [0.85 – 0.97]; P = 0.003). Conclusions: These findings demonstrated that both eGFRcre slope and eGFRcys slope were associated with future ESRD risk. eGFRcre slope was not inferior to eGFRcys slope as a predictor of renal outcome in patients with CKD.
원문(PDF)	PDF 원문보기

목록

위로가기