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논문분류	춘계학술대회 초록집
제목	L-Carnitine Treatment Attenuates Renal Tubulointerstitial Fibrosis Induced by Unilateral Ureteral Obstruction
저자	Hui Ying Li
출판정보	2019; 2019(1):
키워드	L-Carnitine \| Unilateral ureteral obstruction \| Oxidative stress \| Apoptosis \| Mitochondria
초록	L-Carnitine (LC) has protective effects against multiorgan damage through its antioxidant capacity and preservation of mitochondrial network. This study examined whether LC treatment would offer nephroprotection in a rat model of unilateral ureteral obstruction (UUO) and an in vitro study. Sprague-Dawley rats underwent UUO and treated daily LC for 7 or 14 days. The influence of LC on UUO was evaluated by means of histopathology, gene expression, oxidative stress, apoptosis and autophagy, mitochondrial function, and AKT/PI3K signaling pathway. In addition, human kidney cells (HK-2) subjected to H2O2 were treated with LC. LC suppressed inflammatory mediators (monocyte chemoattractant protein-1 and osteopontin) and inhibited fibrotic cytokine transforming growth factor-β1 (TGF-β1) expression, resulting in a significant attenuation of tubulointerstitial fibrosis (TIF) in a time-dependent manner. Increased oxidative stress induced by UUO was associated with impairment of mitochondrial function, and excessive apoptosis and autophagy via AKT/PI3K dependent signaling pathway, and this was reversed with addition of LC. In H2O2-treated HK-2 cells, LC improved cell viability and reduced reactive oxygen species production. Moreover, LC treatment decreased H2O2-induced upregulation of TGF-β1 expression and AKT/PI3K activation in HK-2 cells. L-Carnitine protects against the progression of TIF in obstructed kidney.
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