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논문분류	춘계학술대회 초록집
제목	Osteoprotegerin is Associated with Development of Coronary Artery Calcification But Not Severity and Progression in Non-dialysis Chronic Kidney Disease: results from the KNOW CKD study
저자	Seon Ha Baek, Sun Ryoung Choi, Jang Won Seo, Ja-Ryong Koo, Sejoong Kim, Ho Jun Chin, Dong-Wan Chae
출판정보	2019; 2019(1):
키워드	osteoprotegerin \| coronary artery calcium score \| chonic kidney disease
초록	Coronary artery calcifications (CAC) are recognized as a predictor of all-cause and cardiovascular mortality in chronic kidney disease (CKD). Osteoprotegerin (OPG) could be a marker of vascular calcification presence and extent. The purpose of this study was to evaluate relationships between OPG levels and presence/severity/progression of CAC score in nondialysis CKD patients. We prospectively enrolled 1974 CKD patients (1180 male/794 female, mean age: 53.2 years) who had OPG and electron beam computed tomography (CT) or multi-detector CT for CAC scoring at baseline. A CAC score of > 400 Agatston unit (AU) s was used to define severe CAC. In term of definition for CAC progression: among those with no baseline CAC, incidence was defined as an annual increase in CAC score ≥ 5 AUs. Among those with baseline CAC, progression was defined as 15% annual increase. Mean serum concentrations of OPG amounted to 6.79 ± 3.53 pmol/L. Among 1974 patients, 1011 (51.2 %) had CAC score >0 and 209 (10.6 %) had scores > 400. Higher OPG levels were associated with the present CAC but not severe CAC at baseline. [LnOPG, presence: OR =1.832, P <0.001; severe CAC: OR =1.700, P =0.070]. Among 872 patients with 4-year follow up CAC scores, 22 (4.9%) participants without CAC at baseline had incident CAC and 243 (63.8%) participants with CAC at baseline had CAC progression. Among subjects without CAC at baseline, higher OPG levels were associated with incident CAC (LnOPG, OR = 4.800. P = 0.024). However, OPG were not associated with CAC progression among participants with CAC at baseline or in total. Our results indicated that higher serum OPG levels are associated with the presence and development of CAC non-dialyzed CKD patients. However, OPG does not seem to be involved in severity and progression of CAC.
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