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논문분류	춘계학술대회 초록집
제목	Clinical significance of urinary sodium excretion on residual renal function in patients with peritoneal dialysis
저자	Yumi Yang, Hye-Young Kim, Soon Kil Kwon, Sun Moon Kim, Hyun-Jeong Cho
출판정보	2019; 2019(1):
키워드	peritonel dialysis \| residual renal function \| sodium removal
초록	Residual renal function (RRF) is a strong predictor of mortality in patients with peritoneal dialysis. It has been reported that higher baseline daily diuresis is an important risk factors for rapid RRF decline during the first year of peritoneal dialysis. The aim of this study was to determine the effect of sodium removal on the decrease of RRF in peritoneal dialysis patients. The study group included 41 patients with peritoneal dialysis (Age; 51±11 years),, including 28 on continuous ambulatory peritoneal dialysis (CAPD) and 13 on automated peritoneal dialysis (APD). We evaluated RRF, 24 hour urine volume, 24 hour urine sodium, dialysate volume, dialysate sodium, peritoneal equilibration test, and dialysis adequacy parameters including total weekly clearance of urea and creatinine, at baseline and at 15 months. RRF(mL/min/1.73 m2) was calculated as the average of creatinine clearance and urea clearance in a 24 hour urine collection. We compared parameters according to the monthly decrease rate of RRF and baseline renal sodium removal. The monthly decrease rate of RRF was significantly higher in the high urinary sodium group compared to low urinary sodium group (-1.32±1.45 vs -0.48±0.19, p= 0.02). The monthly decrease rate of RRF was related to baseline urinary sodium excretion(r=-0.55, p=0.01). In rapid loss of RRF group, there is significant higher urinary sodium excretion at baseline compared to slow loss of RRF group (97.7±61.4 vs 53.4±34.5 mEq/d, p=0.01). There is no significant difference in dialysate volume, dialysate sodium removal, diabetes, peritoneal permeability, and dialysis adequacy parameters between rapid and slow loss of RRF group. These results suggest that the higher baseline urinary sodium excretion influence on rapid RRF decline in peritoneal dialysis. The evaluation of urinary sodium excretion in peritoneal dialysis patients may be helpful in predicting the rate of RRF loss
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