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논문분류	춘계학술대회 초록집
제목	Functional anatomy for urinary acidification
저자	Tae-Hwan Kwon
출판정보	2019; 2019(1):
키워드	urinary acidification \| sodim-hydrogen exchanger \| sodim-bicarbonate cotransporter \| hydrogen pump \| anion exchanger
초록	Kidney plays a critical role in acid-base homeostasis by the reabsorption of filtered bicarbonate (HCO3-) and the generation of new HCO3-. In the proximal tubule, HCO3-reabsorption occurs via the transcellular coupling of the apical Na+/H+exchanger with the basolateral Na+(HCO3-) cotransporter, which plays a critical role in mediating electrogenic bicarbonate efflux. In the cortical distal nephron, acid secretion is primarily mediated by a vacuolar H+-ATPase and H+-K+-ATPase located in the apical plasma membranes of type A-intercalated cells. Basolateral bicarbonate efflux is mediated by the anion exchanger AE1 in this cell type. In type B- intercalated cells, the vacuolar H+-ATPase is located on the basolateral membrane. This cell type is thought to mediate collecting duct HCO3- secretion via an apical anion exchanger pendrin. In addition to the Na+(HCO3-) cotransporter, which mediates electrogenic basolateral HCO3- transport in the proximal tubule, other members of the Na+(HCO3-) cotransporter family have been identified and functionally characterized. Renal ammonia excretion is the predominant component of renal net acid excretion. In the proximal tubule, the apical Na+/H+exchanger is a major mechanism of preferential NH4+ secretion. In the thick ascending limb of Henle, the apical Na+-K+-2Cl- cotransporter is a major route to ammonia reabsorption and the basolateral Na+/H+exchanger appears to be the basolateral NH4+ exit. The collecting duct is a major site for renal ammonia secretion. The Rhesus glycoproteins, Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg), are recently recognized ammonia transporters in the distal tubule and collecting duct. The localization and function of these acid-base transporters in the kidney tubules are to be discussed.
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