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논문분류	춘계학술대회 초록집
제목	Chaga mushroom-induced oxalate nephropathy manifested by nephrotic syndrome
저자	Ohyun Kwon, Yaerim Kim, Jin Hyuk Paek, Woo Yeong Park, Seungyeup Han, Hyungchan Sin, Kyubok Jin
출판정보	2020; 2020(1):
키워드	acute kidney injury \| nephrotic syndrome \| calcium oxalate \| therapy
초록	Chaga is a fungus in the family Hymenochaetaceae. It is parasitic on birch and other trees. Some people consider Chaga to be medicinal. Chaga mushroom is rich in a wide variety of vitamins, minerals, and nutrients. It has been reported that it suppresses cancer progression through anti-inflammatory and anti-oxidant effects. Nevertheless, in the recent report, Chaga mushroom can result in acute oxalate nephropathy. We report a case of acute oxalate nephropathy with nephrotic syndrome in a 69-year-old male, associated with the ingestion of Chaga mushroom powder (2-3 teaspoons per day) and vitamin C for past three months. He had acute kidney injury with clinical manifestations of nephrotic syndrome. Because his kidney function did not improve, he received hemodialysis and renal biopsy. Pathologic findings showed focal acute tubular injury, calcium oxalate crystals in tubules, interstitial fibrosis and tubular atrophy in light microscopy, and effacement of podocyte foot process in electron microscopy. High dose of steroid (intravenous hydrocortisone 500mg twice a day for 3 days and oral prednisolone 1mg/kg) was treated with hemodialysis. Finally, his kidney function recovered just one month after the start of treatment, and nephrotic syndrome was also remitted completely.
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